Synthesis, characterization, and antimicrobial activity of novel substituted 2H-chromenyl acrylates
- Authors: Subhashini N.J.1, Ravi M.1, Cherupally D.2, China Raju B.2, Reddy E.V.2, Bee H.3
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Affiliations:
- Department of Pharmacy, University College of Technology
- Natural Products Chemistry Division
- Department of Microbiology, University College of Science
- Issue: Vol 86, No 12 (2016)
- Pages: 2900-2905
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217365
- DOI: https://doi.org/10.1134/S1070363216120586
- ID: 217365
Cite item
Abstract
The present study deals with conventional Witting olefination of 2H-chromene-3-carbaldehydes with stabilized ylide in the presence of dichloromethane to afford (2E)-ethyl-3-(4-chloro-2H-chromen-3-yl) acrylate derivatives. All the products were found to have E-geometry at C=C bond. The synthesized compounds were characterized by spectral data such as IR, 1H NMR and MS. Compounds were screened for antimicrobial activity against strains of gram positive, gram negative bacterial and fungal strains. All compounds showed good antibacterial and antifungal activity.
About the authors
N. J. P. Subhashini
Department of Pharmacy, University College of Technology
Author for correspondence.
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
M. Ravi
Department of Pharmacy, University College of Technology
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
D. Cherupally
Natural Products Chemistry Division
Email: njsubhashini@yahoo.co.in
India, Tarnaka
B. China Raju
Natural Products Chemistry Division
Email: njsubhashini@yahoo.co.in
India, Tarnaka
E. V. Reddy
Natural Products Chemistry Division
Email: njsubhashini@yahoo.co.in
India, Tarnaka
H. Bee
Department of Microbiology, University College of Science
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007