Sc(OTf)3 catalyzed synthesis of novel 6-phenyl-6H-chromeno[4,3-b]quinolines and evaluation of their cytotoxicity
- Authors: Rao Y.J.1,2, Reddy E.P.1, Thirupathi G.1, Yadaiah goud E.1, Sowjanya M.3, Hemasri Y.1
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Affiliations:
- Department of Chemistry
- Department Chemistry
- Center for Chemical Biology
- Issue: Vol 86, No 7 (2016)
- Pages: 1730-1734
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215803
- DOI: https://doi.org/10.1134/S1070363216070318
- ID: 215803
Cite item
Abstract
Novel 6-phenyl-6H-chromeno[4,3-b]quinoline derivatives have been prepared by reaction of 4-chloro-2-phenyl-2H-chromene-3-carbaldehyde with various aromatic amines using 5 mol % of Sc(OTf)3 in acetonitile. This is the first example of one-pot synthesis of 6-phenyl-6H-chromeno[4,3-b]quinoline from 4-chloro-2-phenyl-2H-chromene-3-carbaldehyde at ambient temperature. Preliminary evaluation of cytotoxic activity of these chromeno[4,3-b]quinoline derivatives has been carried out. Some products exhibited anti cancer activity against two carcinoma cell lines A549 and B-16.
About the authors
Y. Jayaprakash Rao
Department of Chemistry; Department Chemistry
Email: pravardhan1@gmail.com
India, Hyderabad, Telangana, 500007; Nizamabad, 503322
E. Pravardhan Reddy
Department of Chemistry
Author for correspondence.
Email: pravardhan1@gmail.com
India, Hyderabad, Telangana, 500007
G. Thirupathi
Department of Chemistry
Email: pravardhan1@gmail.com
India, Hyderabad, Telangana, 500007
E. Yadaiah goud
Department of Chemistry
Email: pravardhan1@gmail.com
India, Hyderabad, Telangana, 500007
M. Sowjanya
Center for Chemical Biology
Email: pravardhan1@gmail.com
India, Hyderabad, 500007
Y. Hemasri
Department of Chemistry
Email: pravardhan1@gmail.com
India, Hyderabad, 500001