Email this article Synthesis, Structure, and Biological Activity of 4-R-4-Oxo-2-[2-(phenylamino)benzoyl]hydrazinylidene-N-hetarylbutanamides
- Authors: Kizimova I.A.1, Igidov N.M.1, Dmitriev M.V.2, Chashchina S.V.1,2, Makhmudov R.R.2,3, Siutkina A.I.1
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Affiliations:
- Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
- Perm State National Research University
- Federal Research Center for Medical and Preventive Health Risk Management Technologies
- Issue: Vol 89, No 12 (2019)
- Pages: 2345-2352
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223186
- DOI: https://doi.org/10.1134/S107036321912003X
- ID: 223186
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Abstract
Decyclization of N′-[5-R-2-oxofuran-3(2H)-ylidene]-2-(phenylamino)benzohydrazides under the action of heterocyclic amines leads to the formation of N-hetaryl-4-R-4-oxo-2-[2-(phenylamino)benzoyl]hydrazinylidenebutanamides. Antinociceptive and anti-inflammatory activity of the obtained compounds was studied.
About the authors
I. A. Kizimova
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: icekingakiratotsuka@gmail.com
Russian Federation, Perm, 614990
N. M. Igidov
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Email: icekingakiratotsuka@gmail.com
Russian Federation, Perm, 614990
M. V. Dmitriev
Perm State National Research University
Email: icekingakiratotsuka@gmail.com
Russian Federation, Perm, 614068
S. V. Chashchina
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State National Research University
Email: icekingakiratotsuka@gmail.com
Russian Federation, Perm, 614990; Perm, 614068
R. R. Makhmudov
Perm State National Research University; Federal Research Center for Medical and Preventive Health Risk Management Technologies
Email: icekingakiratotsuka@gmail.com
Russian Federation, Perm, 614068; Perm, 614045
A. I. Siutkina
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Email: icekingakiratotsuka@gmail.com
Russian Federation, Perm, 614990
