Pyrazoles and Isoxazoles Based Sulfanilamide and Phenazone as Antimicrobial Agents: Synthesis and Biological Activity

A. H. Moustafa; H. A. El-Sayed; S. M. El Rayes; H. A. Morsy; S. H. Abd-allah; H. F. Ismail; M. M. Abd El-Aal

doi:10.1134/S1070363219110240

Pyrazoles and Isoxazoles Based Sulfanilamide and Phenazone as Antimicrobial Agents: Synthesis and Biological Activity

Authors: Moustafa A.H.¹, El-Sayed H.A.¹, El Rayes S.M.¹, Morsy H.A.², Abd-allah S.H.³, Ismail H.F.¹, Abd El-Aal M.M.¹
Affiliations:
1. Department of Chemistry, Faculty of Science
2. Higher Institution of Engineering & Modern Technology
3. Department of Biochemistry, Faculty of Medicine
Issue: Vol 89, No 11 (2019)
Pages: 2314-2320
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/223179
DOI: https://doi.org/10.1134/S1070363219110240
ID: 223179

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Abstract

New pyrazole and pyridine derivatives have been synthesized from sulfanilamide and phenazone via diazotization and coupling with a wide range of α-CH acids followed by heterocyclization with hydrazine derivative, hydroxylamine and cyanoacetamide. The antimicrobial tests of the products demonstrate high to moderate activity against Gram (−ve) bacteria and the tested fungi. No positive action of the products is observed against Gram (+ve) bacteria.