Отправить статью по E-mail Synthesis of Tetradecapentaenoic Acid Derivatives
- Авторы: Kolodyazhnaya A.1, Kolodyazhny O.1
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Учреждения:
- V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
- Выпуск: Том 89, № 10 (2019)
- Страницы: 1998-2004
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223106
- DOI: https://doi.org/10.1134/S1070363219100037
- ID: 223106
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Аннотация
A 12-stage method for the stereoselective synthesis of tetradecapentaenoic acid derivatives using phosphoric reagents was developed. The key step in the synthesis is the Z-selective Wittig reaction between sorbaldehyde and triphenylphosphonium (6-methoxycarbonyl)hexanilide, as well as the Ramirez-Corey-Fuchs reaction and the Trost-Kazmaier rearrangement. The synthesized (2E,4E,8Z,10E,12E)-N-isobutyltetradeca-2,4,8,10,12-pentaenamide corresponds to a natural compound called γ-Sanshoöl.
Об авторах
A. Kolodyazhnaya
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
Email: olegkol321@gmail.com
Украина, ul. Murmanskaya 1, Kiev, 02094
O. Kolodyazhny
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
Автор, ответственный за переписку.
Email: olegkol321@gmail.com
Украина, ul. Murmanskaya 1, Kiev, 02094
