Email this article Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides
- Authors: Khattab R.R.1, Hassan A.A.2,3, Kutkat O.M.4, Abuzeid K.M.1, Hassan N.A.1,3
-
Affiliations:
- Photochemistry Department
- Chemistry Department, Faculty of Science
- Pharmaceutical Science Department, College of Pharmacy
- Center of Scientific Excellence for Influenza Virus
- Issue: Vol 89, No 8 (2019)
- Pages: 1707-1717
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223051
- DOI: https://doi.org/10.1134/S1070363219080267
- ID: 223051
Cite item
Open Access
Access granted
Subscription Access
Abstract
A hydrazinylthienopyrimidine derivative reacted with a number of monosaccharides in the presence of a catalytic amount of acetic acid giving the corresponding sugar hydrazones, that undergo oxidative cyclization under the action of ferric chloride with formation of triazolo derivatives. Structures of the products have been elucidated from IR, 1H, and 13C NMR data. Antiviral activity of the newly synthesized compounds is tested against influenza virus H5N1.
About the authors
R. R. Khattab
Photochemistry Department
Author for correspondence.
Email: nasserabdelhamid@hotmail.com
Egypt, Dokki, Cairo, 12622
A. A. Hassan
Chemistry Department, Faculty of Science; Pharmaceutical Science Department, College of Pharmacy
Email: rerybadr@gmail.com
Egypt, Suez; Riyadh
O. M. Kutkat
Center of Scientific Excellence for Influenza Virus
Email: rerybadr@gmail.com
Egypt, Dokki, Cairo, 12311
K. M. Abuzeid
Photochemistry Department
Email: rerybadr@gmail.com
Egypt, Dokki, Cairo, 12622
N. A. Hassan
Photochemistry Department; Pharmaceutical Science Department, College of Pharmacy
Author for correspondence.
Email: rerybadr@gmail.com
Egypt, Dokki, Cairo, 12622; Riyadh
