Отправить статью по E-mail Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides
- Авторы: Khattab R.R.1, Hassan A.A.2,3, Kutkat O.M.4, Abuzeid K.M.1, Hassan N.A.1,3
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Учреждения:
- Photochemistry Department
- Chemistry Department, Faculty of Science
- Pharmaceutical Science Department, College of Pharmacy
- Center of Scientific Excellence for Influenza Virus
- Выпуск: Том 89, № 8 (2019)
- Страницы: 1707-1717
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223051
- DOI: https://doi.org/10.1134/S1070363219080267
- ID: 223051
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Аннотация
A hydrazinylthienopyrimidine derivative reacted with a number of monosaccharides in the presence of a catalytic amount of acetic acid giving the corresponding sugar hydrazones, that undergo oxidative cyclization under the action of ferric chloride with formation of triazolo derivatives. Structures of the products have been elucidated from IR, 1H, and 13C NMR data. Antiviral activity of the newly synthesized compounds is tested against influenza virus H5N1.
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R. Khattab
Photochemistry Department
Автор, ответственный за переписку.
Email: nasserabdelhamid@hotmail.com
Египет, Dokki, Cairo, 12622
A. Hassan
Chemistry Department, Faculty of Science; Pharmaceutical Science Department, College of Pharmacy
Email: rerybadr@gmail.com
Египет, Suez; Riyadh
O. Kutkat
Center of Scientific Excellence for Influenza Virus
Email: rerybadr@gmail.com
Египет, Dokki, Cairo, 12311
K. Abuzeid
Photochemistry Department
Email: rerybadr@gmail.com
Египет, Dokki, Cairo, 12622
N. Hassan
Photochemistry Department; Pharmaceutical Science Department, College of Pharmacy
Автор, ответственный за переписку.
Email: rerybadr@gmail.com
Египет, Dokki, Cairo, 12622; Riyadh
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