Microwave Assisted Synthesis and Antimicrobial Activity of Novel 1,3,4-Thiadiazoles and 1,2,4-Triazoles Derived from 2-(3-Fluorophenyl)-4-methylthiazole-5-carbohydrazide
- Authors: Dengale S.G.1, Karale B.K.2, Akolkar H.N.2, Darekar N.R.2, Deshmukh K.K.1
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Affiliations:
- P.G. and Research, Department of Chemistry, Sangamner Nagarpalika Arts
- P.G. and Research, Department of Chemistry
- Issue: Vol 89, No 7 (2019)
- Pages: 1535-1540
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223007
- DOI: https://doi.org/10.1134/S1070363219070259
- ID: 223007
Cite item
Abstract
The precursors 2-{[2-(3-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}-N-phenylhydrazinecarbothioamides are synthesized from 2-(3-fluorophenyl)-4-methylthiazole-5-carbohydrazide and aryl isothiocyanates. MW irradiation of the precursors under alkali or acidic conditions led to the products of cyclization 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-N-phenyl-1,3,4-thiadiazol-2-amine or 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-4-phenyl-4H-1,2,4-triazole-3-triiol, accordingly. Structures of the synthesized compounds are confirmed by IR, 1H, and 13C NMR, and mass spectra. All products are tested in vitro for their antibacterial and antifungal activity.
About the authors
S. G. Dengale
P.G. and Research, Department of Chemistry, Sangamner Nagarpalika Arts
Email: hemantakolkar@gmail.com
India, Sangamner, Maharashtra, 422605
B. K. Karale
P.G. and Research, Department of Chemistry
Email: hemantakolkar@gmail.com
India, Ahmednagar, Maharashtra, 414001
H. N. Akolkar
P.G. and Research, Department of Chemistry
Email: hemantakolkar@gmail.com
India, Ahmednagar, Maharashtra, 414001
N. R. Darekar
P.G. and Research, Department of Chemistry
Email: hemantakolkar@gmail.com
India, Ahmednagar, Maharashtra, 414001
K. K. Deshmukh
P.G. and Research, Department of Chemistry, Sangamner Nagarpalika Arts
Author for correspondence.
Email: hemantakolkar@gmail.com
India, Sangamner, Maharashtra, 422605