Microwave Assisted Synthesis and Antimicrobial Activity of Novel 1,3,4-Thiadiazoles and 1,2,4-Triazoles Derived from 2-(3-Fluorophenyl)-4-methylthiazole-5-carbohydrazide
- 作者: Dengale S.1, Karale B.2, Akolkar H.2, Darekar N.2, Deshmukh K.1
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隶属关系:
- P.G. and Research, Department of Chemistry, Sangamner Nagarpalika Arts
- P.G. and Research, Department of Chemistry
- 期: 卷 89, 编号 7 (2019)
- 页面: 1535-1540
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223007
- DOI: https://doi.org/10.1134/S1070363219070259
- ID: 223007
如何引用文章
详细
The precursors 2-{[2-(3-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]carbonyl}-N-phenylhydrazinecarbothioamides are synthesized from 2-(3-fluorophenyl)-4-methylthiazole-5-carbohydrazide and aryl isothiocyanates. MW irradiation of the precursors under alkali or acidic conditions led to the products of cyclization 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-N-phenyl-1,3,4-thiadiazol-2-amine or 5-[2-(3-fluorophenyl)-4-methylthiazol-5-yl]-4-phenyl-4H-1,2,4-triazole-3-triiol, accordingly. Structures of the synthesized compounds are confirmed by IR, 1H, and 13C NMR, and mass spectra. All products are tested in vitro for their antibacterial and antifungal activity.
作者简介
S. Dengale
P.G. and Research, Department of Chemistry, Sangamner Nagarpalika Arts
Email: hemantakolkar@gmail.com
印度, Sangamner, Maharashtra, 422605
B. Karale
P.G. and Research, Department of Chemistry
Email: hemantakolkar@gmail.com
印度, Ahmednagar, Maharashtra, 414001
H. Akolkar
P.G. and Research, Department of Chemistry
Email: hemantakolkar@gmail.com
印度, Ahmednagar, Maharashtra, 414001
N. Darekar
P.G. and Research, Department of Chemistry
Email: hemantakolkar@gmail.com
印度, Ahmednagar, Maharashtra, 414001
K. Deshmukh
P.G. and Research, Department of Chemistry, Sangamner Nagarpalika Arts
编辑信件的主要联系方式.
Email: hemantakolkar@gmail.com
印度, Sangamner, Maharashtra, 422605