Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins)
- Authors: Bogdanov A.V.1, Zaripova I.F.1, Mustafina L.K.1, Voloshina A.D.1, Sapunova A.S.1, Kulik N.V.1, Mironov V.F.1
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
- Issue: Vol 89, No 7 (2019)
- Pages: 1368-1376
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222979
- DOI: https://doi.org/10.1134/S107036321907003X
- ID: 222979
Cite item
Abstract
Alkylation of isatin with 1,ω-dihaloalkanes afforded bis(heterocycles) connected by an oligomethylene linker. The reaction of the resulting bis(isatins) with Girard’s T and Girard’s P reagents led to the formation of symmetrical water-soluble acyl hydrazones with high yields. Evaluation of antimicrobial activity of new compounds showed the dependence of the activity level on the hydrocarbon spacer length. The selective activity of nona- and decamethylene derivatives was established with respect to gram-positive bacteria S. aureus 209p and B. cereus 8035. Low hematotoxicity of the obtained heterocycles was revealed.
Keywords
About the authors
A. V. Bogdanov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Author for correspondence.
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
I. F. Zaripova
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
L. K. Mustafina
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. D. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. S. Sapunova
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
N. V. Kulik
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
V. F. Mironov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
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