Synthesis and Study of Antimicrobial Activity of Water-Soluble Ammonium Acylhydrazones Based on New 1,ω-Alkylenebis(isatins)
- Autores: Bogdanov A.1, Zaripova I.1, Mustafina L.1, Voloshina A.1, Sapunova A.1, Kulik N.1, Mironov V.1
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Afiliações:
- Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
- Edição: Volume 89, Nº 7 (2019)
- Páginas: 1368-1376
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222979
- DOI: https://doi.org/10.1134/S107036321907003X
- ID: 222979
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Resumo
Alkylation of isatin with 1,ω-dihaloalkanes afforded bis(heterocycles) connected by an oligomethylene linker. The reaction of the resulting bis(isatins) with Girard’s T and Girard’s P reagents led to the formation of symmetrical water-soluble acyl hydrazones with high yields. Evaluation of antimicrobial activity of new compounds showed the dependence of the activity level on the hydrocarbon spacer length. The selective activity of nona- and decamethylene derivatives was established with respect to gram-positive bacteria S. aureus 209p and B. cereus 8035. Low hematotoxicity of the obtained heterocycles was revealed.
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Sobre autores
A. Bogdanov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Autor responsável pela correspondência
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
I. Zaripova
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
L. Mustafina
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
A. Sapunova
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
N. Kulik
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
V. Mironov
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center
Email: abogdanov@inbox.ru
Rússia, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
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