Synthesis, Structure, and Biological Activity of Copper and Cobalt Coordination Compounds with Substituted 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamides
- Authors: Burduniuc O.S.1,2, Tsapkov V.I.3, Rudic V.F.4, Gulea A.P.3, Graur V.O.3, Chumakov Y.M.5,6, Petrenko P.A.5, Balan G.G.1
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Affiliations:
- Testemitanu State University of Medicine and Pharmacy
- National Agency of Public Health
- State University of Moldova
- Institute of Microbiology and Biotechnology
- Institute of Applied Physics
- Gebze Institute of Technology
- Issue: Vol 89, No 5 (2019)
- Pages: 953-964
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222906
- DOI: https://doi.org/10.1134/S1070363219050153
- ID: 222906
Cite item
Abstract
The reaction of N-(prop-2-en-1-yl)hydrazinecarbothioamide with substituted 2-hydroxybenzaldehydes afforded the corresponding Schiff bases which were used as ligands to obtain copper and cobalt coordination compounds Cu(NL1–6)X · n H2O (X = Cl−, \(\rm{NO}_3^-\); n = 0–3), Co(HL2)2NO3, and Co(NL6)2Cl. The structure of the isolated complexes was determined by NMR spectroscopy and X-ray analysis. The complexes were tested for antimicrobial and antifungal activity against S. aureus, E. coli, and yeast-like fungi. Inhibitory effect of the initial thioamides and their complexes against human myeloid leukemia HL-60 cancer cell line was also studied.
About the authors
O. S. Burduniuc
Testemitanu State University of Medicine and Pharmacy; National Agency of Public Health
Email: vtsapkov@gmail.com
Moldova, Republic of, Kishinev; Kishinev
V. I. Tsapkov
State University of Moldova
Author for correspondence.
Email: vtsapkov@gmail.com
Moldova, Republic of, ul. Mateevicha 60, Kishinev
V. F. Rudic
Institute of Microbiology and Biotechnology
Email: vtsapkov@gmail.com
Moldova, Republic of, Kishinev
A. P. Gulea
State University of Moldova
Email: vtsapkov@gmail.com
Moldova, Republic of, ul. Mateevicha 60, Kishinev
V. O. Graur
State University of Moldova
Email: vtsapkov@gmail.com
Moldova, Republic of, ul. Mateevicha 60, Kishinev
Yu. M. Chumakov
Institute of Applied Physics; Gebze Institute of Technology
Email: vtsapkov@gmail.com
Moldova, Republic of, Kishinev; Gebze/Kocaeli, Çayirova
P. A. Petrenko
Institute of Applied Physics
Email: vtsapkov@gmail.com
Moldova, Republic of, Kishinev
G. G. Balan
Testemitanu State University of Medicine and Pharmacy
Email: vtsapkov@gmail.com
Moldova, Republic of, Kishinev
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