Design and Synthesis of Novel β-Carboline Linked Amide Derivatives as Anticancer Agents

B. Ravinaik; D. Ramachandran; M. V. Basaveswara Rao

doi:10.1134/S1070363219030241

Design and Synthesis of Novel β-Carboline Linked Amide Derivatives as Anticancer Agents

Authors: Ravinaik B.¹, Ramachandran D.¹, Basaveswara Rao M.V.²
Affiliations:
1. Department of Chemistry
2. Department of Chemistry, Dr. MRAR. PG Centre
Issue: Vol 89, No 3 (2019)
Pages: 511-516
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222803
DOI: https://doi.org/10.1134/S1070363219030241
ID: 222803

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Abstract

A novel series of β-carboline linked amide derivatives is synthesized. The compounds are screened for their anticancer activity against MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) cancer cell lines. The compounds 12b and 12h demonstrate the activity higher than the standard drug etoposide.