Email this article Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4
- Authors: Ragha Suma V.1,2, Sreenivasulu R.3, Subramanyam M.2, Rao K.R.4
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Affiliations:
- Department of Chemistry, GITAM Institute of Science
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Department of Chemistry, GITAM Institute of Technology
- Issue: Vol 89, No 3 (2019)
- Pages: 499-504
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222800
- DOI: https://doi.org/10.1134/S1070363219030228
- ID: 222800
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Abstract
A new series of amide derivatives of structurally modified combretastatin-A4 10a–10j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The products are tested for their anticancer activity towards human cancer cell lines, MCF-7 (breast), A-549 (lung), Colo-205 (colon), and A-2780 (ovarian). The compounds 10b, 10c, and 10d demonstrate the most promising activity.
About the authors
V. Ragha Suma
Department of Chemistry, GITAM Institute of Science; Department of Chemistry
Email: rammohanrao.k@gmail.com
India, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045; Bhadrachalam, Telangana, 507111
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rammohanrao.k@gmail.com
India, Kakinada, Andhra Pradesh, 533003
M. Subramanyam
Department of Chemistry
Email: rammohanrao.k@gmail.com
India, Khammam, Telangana, 507002
K. Ram Mohan Rao
Department of Chemistry, GITAM Institute of Technology
Author for correspondence.
Email: rammohanrao.k@gmail.com
India, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045
