电邮这篇文章 Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4
- 作者: Ragha Suma V.1,2, Sreenivasulu R.3, Subramanyam M.2, Rao K.4
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隶属关系:
- Department of Chemistry, GITAM Institute of Science
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Department of Chemistry, GITAM Institute of Technology
- 期: 卷 89, 编号 3 (2019)
- 页面: 499-504
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222800
- DOI: https://doi.org/10.1134/S1070363219030228
- ID: 222800
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详细
A new series of amide derivatives of structurally modified combretastatin-A4 10a–10j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The products are tested for their anticancer activity towards human cancer cell lines, MCF-7 (breast), A-549 (lung), Colo-205 (colon), and A-2780 (ovarian). The compounds 10b, 10c, and 10d demonstrate the most promising activity.
作者简介
V. Ragha Suma
Department of Chemistry, GITAM Institute of Science; Department of Chemistry
Email: rammohanrao.k@gmail.com
印度, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045; Bhadrachalam, Telangana, 507111
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rammohanrao.k@gmail.com
印度, Kakinada, Andhra Pradesh, 533003
M. Subramanyam
Department of Chemistry
Email: rammohanrao.k@gmail.com
印度, Khammam, Telangana, 507002
K. Rao
Department of Chemistry, GITAM Institute of Technology
编辑信件的主要联系方式.
Email: rammohanrao.k@gmail.com
印度, Rushikonda, Visakhapatnam, Andhra Pradesh, 530045
