Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

A. H. Ahmed; A. Ebead; H. Afifi; A. A.-H. Abdel-Rahman

doi:10.1134/S1070363219020294

Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

Authors: Ahmed A.H.¹, Ebead A.², Afifi H.³, Abdel-Rahman A.A.²
Affiliations:
1. Chemistry Department, Faculty of Medicinal Science
2. Chemistry Department, Faculty of Science
3. Faculty of Industrial Education
Issue: Vol 89, No 2 (2019)
Pages: 357-363
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222772
DOI: https://doi.org/10.1134/S1070363219020294
ID: 222772

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Abstract

New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.