Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

A. H. Ahmed; A. Ebead; H. Afifi; A. A.-H. Abdel-Rahman

doi:10.1134/S1070363219020294

Synthesis and Antitumor Evaluation of Novel Alkylated Hydantoin and Thiohydantoin Derivatives

Autores: Ahmed A.¹, Ebead A.², Afifi H.³, Abdel-Rahman A.²
Afiliações:
1. Chemistry Department, Faculty of Medicinal Science
2. Chemistry Department, Faculty of Science
3. Faculty of Industrial Education
Edição: Volume 89, Nº 2 (2019)
Páginas: 357-363
Seção: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222772
DOI: https://doi.org/10.1134/S1070363219020294
ID: 222772

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Resumo

New alkylated hydantoin as well as 2-thiohydantoins were synthesized for broadening the library of compounds screened for antitumor activity. Antitumor activity of the new compounds was evaluated against breast cancer cell line (MCF-7) and demonstrated moderate to good activity.