New Acylhydrazones of Indole Series and Their Metal Complexes

Abstract

By the reaction of 2-chloroindole-3-carbaldehyde with acylhydrazones new acylhydrazones of the indole series have been synthesized, and their structure, the possibility of cyclization to pyrazoloindoles, and complexing properties have been studied. By means of quantum chemical DFT calculations taking into account the solvent effect it was shown that the reaction of 2-chloroindole-3-carbaldehyde and the corresponding acylhydrazine is an exothermic process, irrespective of which final product is formed, indolemethylenehydrazide or pyrazoloindole. Therefore, both possible transformations in the studied reacting system are controlled kinetically and not thermodynamically.