Synthesis, spectral characterization, DNA interaction, antioxidant, and antimicrobial studies of new water soluble metal(II) complexes of morpholine based ligand

Abstract

A new series of metal(II) complexes 1–5 of the type [M(L)(AcO)₂H₂O], where L is a bidentate ligand, 2-(3-morpholinopropylimino)methylphenol and M is Mn(II) (1), Co(II) (2), Ni(II) (3), Cu(II) (4), and Zn(II) (5), have been isolated and characterized by physico-chemical and spectral methods. Spectroscopic data supported the square pyramidal geometry around the central metal ion in the complexes 1–5. Absorption spectra and viscometric data indicated that the complexes 1–5 interacted with calf thymus (CT) DNA via intercalative strategy. Cleavage activities of complexes 1–5 with CT DNA were analyzed by gelelectrophoretic method. The in vitro antioxidant activity of complexes 1–5 was tested using the DPPH assay. The complexes 1–5 have been tested for antimicrobial activity against some pathogenic bacterial and fungal species by the agar well diffusion method.