Email this article Synthesis of prolyl-glutamate phosphoisostere
- Authors: Dmitriev M.E.1, Vinyukov A.V.1, Lednev B.V.1, Ragulin V.V.1
-
Affiliations:
- Institute of Physiologically Active Substances
- Issue: Vol 87, No 10 (2017)
- Pages: 2489-2492
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221527
- DOI: https://doi.org/10.1134/S1070363217100358
- ID: 221527
Cite item
Open Access
Access granted
Subscription Access
Abstract
A method for the synthesis of prolyl-glutamate phosphoisostere by cyclic amidoalkylation of phosphonous acid containing a structural isostere of glutamic acid was developed. A combination of amide and carbonyl moieties in the 4-N-Cbz-aminobutyraldehyde molecule allows cyclization with in situ generation of a cyclic pyrrolidine Schiff base followed by its Arbuzov type phosphorylation.
About the authors
M. E. Dmitriev
Institute of Physiologically Active Substances
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
A. V. Vinyukov
Institute of Physiologically Active Substances
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
B. V. Lednev
Institute of Physiologically Active Substances
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
V. V. Ragulin
Institute of Physiologically Active Substances
Author for correspondence.
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432
