Synthesis of prolyl-glutamate phosphoisostere
- Авторы: Dmitriev M.1, Vinyukov A.1, Lednev B.1, Ragulin V.1
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Учреждения:
- Institute of Physiologically Active Substances
- Выпуск: Том 87, № 10 (2017)
- Страницы: 2489-2492
- Раздел: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221527
- DOI: https://doi.org/10.1134/S1070363217100358
- ID: 221527
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Аннотация
A method for the synthesis of prolyl-glutamate phosphoisostere by cyclic amidoalkylation of phosphonous acid containing a structural isostere of glutamic acid was developed. A combination of amide and carbonyl moieties in the 4-N-Cbz-aminobutyraldehyde molecule allows cyclization with in situ generation of a cyclic pyrrolidine Schiff base followed by its Arbuzov type phosphorylation.
Об авторах
M. Dmitriev
Institute of Physiologically Active Substances
Email: rvalery@dio.ru
Россия, Severnyi proezd 1, Chernogolovka, 142432
A. Vinyukov
Institute of Physiologically Active Substances
Email: rvalery@dio.ru
Россия, Severnyi proezd 1, Chernogolovka, 142432
B. Lednev
Institute of Physiologically Active Substances
Email: rvalery@dio.ru
Россия, Severnyi proezd 1, Chernogolovka, 142432
V. Ragulin
Institute of Physiologically Active Substances
Автор, ответственный за переписку.
Email: rvalery@dio.ru
Россия, Severnyi proezd 1, Chernogolovka, 142432