Email this article Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide
- Authors: Nurkenov O.A.1, Satpaeva Z.B.1, Schepetkin I.A.2,3, Khlebnikov A.I.4,5, Turdybekov K.M.6, Seilkhanov T.M.7, Fazylov S.D.1
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Affiliations:
- Institute of Organic Synthesis and Coal Chemistry of Kazakhstan
- Montana State University
- Russian-Speaking Academic Science Association (RASA) Center
- National Research Tomsk Polytechnic University
- Polzunov Altai State Technical University
- Buketov Karaganda State University
- Ualikhanov Kokshetau State University
- Issue: Vol 87, No 10 (2017)
- Pages: 2299-2306
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221403
- DOI: https://doi.org/10.1134/S1070363217100097
- ID: 221403
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Abstract
A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin Е and(or) elastase of human neutrophils has been determined.
About the authors
O. A. Nurkenov
Institute of Organic Synthesis and Coal Chemistry of Kazakhstan
Author for correspondence.
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008
Zh. B. Satpaeva
Institute of Organic Synthesis and Coal Chemistry of Kazakhstan
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008
I. A. Schepetkin
Montana State University; Russian-Speaking Academic Science Association (RASA) Center
Email: nurkenov_oral@mail.ru
United States, Bozeman; Tomsk
A. I. Khlebnikov
National Research Tomsk Polytechnic University; Polzunov Altai State Technical University
Email: nurkenov_oral@mail.ru
Russian Federation, Tomsk; Barnaul
K. M. Turdybekov
Buketov Karaganda State University
Email: nurkenov_oral@mail.ru
Kazakhstan, Karaganda
T. M. Seilkhanov
Ualikhanov Kokshetau State University
Email: nurkenov_oral@mail.ru
Kazakhstan, Kokshetau
S. D. Fazylov
Institute of Organic Synthesis and Coal Chemistry of Kazakhstan
Email: nurkenov_oral@mail.ru
Kazakhstan, ul. Alikhanova 1, Karaganda, 100008
