Synthesis of new daunorubicin  N -derivatives by one-step reductive amination

O. I. Artyushin; E. V. Sharova; N. M. Vinogradova; G. K. Genkina; A. A. Moiseeva; A. A. Khodak; V. K. Brel

doi:10.1134/S1070363217060330

Synthesis of new daunorubicin N-derivatives by one-step reductive amination

Authors: Artyushin O.I.¹, Sharova E.V.¹, Vinogradova N.M.¹, Genkina G.K.¹, Moiseeva A.A.¹, Khodak A.A.¹, Brel V.K.¹
Affiliations:
1. Nesmeyanov Institute of Organoelemental Compounds
Issue: Vol 87, No 6 (2017)
Pages: 1323-1326
Section: Letters to the Editor
URL: https://journals.rcsi.science/1070-3632/article/view/220457
DOI: https://doi.org/10.1134/S1070363217060330
ID: 220457

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Abstract

One-step reductive amination of aromatic aldehydes using an anthracycline antibiotic daunorubicin resulted in the preparation of its new N-derivatives, which are of interest as potential antitumor drugs.