Complex formation of daunomycin with poly(vinylpyrrolidone) and poly(ethylene glycol)

Abstract

Complexes of the anthracycline antitumor antibiotic daunomycin with biocompatible polymer carriers, poly(vinylpyrrolidone) and poly(ethylene glycol), have been studied. According to the UV–visible absorption spectroscopy and dynamic light scattering data, variation of the weight ratio of the components leads to the formation of antibiotic–polymer complexes in which the polymer is linked through hydrophobic and electrostatic interactions to certain functional groups of the antibiotic molecules. The concentration constants for the complex formation have been calculated.