Complex formation of daunomycin with poly(vinylpyrrolidone) and poly(ethylene glycol)
- 作者: Borovikova L.1, Titova A.1,2, Kipper A.1, Pisarev O.1,2
-
隶属关系:
- Institute of Macromolecular Compounds
- Peter the Great St. Petersburg Polytechnic University
- 期: 卷 87, 编号 5 (2017)
- 页面: 1031-1037
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/219880
- DOI: https://doi.org/10.1134/S1070363217050231
- ID: 219880
如何引用文章
详细
Complexes of the anthracycline antitumor antibiotic daunomycin with biocompatible polymer carriers, poly(vinylpyrrolidone) and poly(ethylene glycol), have been studied. According to the UV–visible absorption spectroscopy and dynamic light scattering data, variation of the weight ratio of the components leads to the formation of antibiotic–polymer complexes in which the polymer is linked through hydrophobic and electrostatic interactions to certain functional groups of the antibiotic molecules. The concentration constants for the complex formation have been calculated.
作者简介
L. Borovikova
Institute of Macromolecular Compounds
Email: chrom79@yandex.ru
俄罗斯联邦, Bol’shoi pr. V. O. 31, St. Petersburg, 199004
A. Titova
Institute of Macromolecular Compounds; Peter the Great St. Petersburg Polytechnic University
Email: chrom79@yandex.ru
俄罗斯联邦, Bol’shoi pr. V. O. 31, St. Petersburg, 199004; ul. Politekhnicheskaya 29, St. Petersburg, 195251
A. Kipper
Institute of Macromolecular Compounds
Email: chrom79@yandex.ru
俄罗斯联邦, Bol’shoi pr. V. O. 31, St. Petersburg, 199004
O. Pisarev
Institute of Macromolecular Compounds; Peter the Great St. Petersburg Polytechnic University
编辑信件的主要联系方式.
Email: chrom79@yandex.ru
俄罗斯联邦, Bol’shoi pr. V. O. 31, St. Petersburg, 199004; ul. Politekhnicheskaya 29, St. Petersburg, 195251
![](/img/style/loading.gif)