Email this article Design and development of macrocyclization methods for compounds with potential tuberculocidal activity to decrease CYP450 liver cytochrome inhibition
- Authors: Vasilevich N.I.1, Aksenova E.A.1, Aksenova A.A.1, Afanasyev I.I.1
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Affiliations:
- New Scientific Technologies
- Issue: Vol 87, No 4 (2017)
- Pages: 717-730
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/219195
- DOI: https://doi.org/10.1134/S1070363217040107
- ID: 219195
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Abstract
A procedure for macrocyclization of compounds with potential tuberculocidal activity was developed in order to obtaining compounds with a lower degree of inhibition of the key CYP 3A4 cytochrome.
About the authors
N. I. Vasilevich
New Scientific Technologies
Author for correspondence.
Email: nvasilevich@asinex.com
Russian Federation, ul. Geroev Panfilovtsev 20, Moscow, 125480
E. A. Aksenova
New Scientific Technologies
Email: nvasilevich@asinex.com
Russian Federation, ul. Geroev Panfilovtsev 20, Moscow, 125480
A. A. Aksenova
New Scientific Technologies
Email: nvasilevich@asinex.com
Russian Federation, ul. Geroev Panfilovtsev 20, Moscow, 125480
I. I. Afanasyev
New Scientific Technologies
Email: nvasilevich@asinex.com
Russian Federation, ul. Geroev Panfilovtsev 20, Moscow, 125480
