Synthesis of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2 Н ,5 Н )-diones

O. E. Nasakin; M. I. Kazantseva; V. L. Gein

doi:10.1134/S107036321701025X

Synthesis of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2Н,5Н)-diones

Authors: Nasakin O.E.¹, Kazantseva M.I.¹, Gein V.L.²
Affiliations:
1. Chuvash State University
2. Perm State Pharmaceutical Academy
Issue: Vol 87, No 1 (2017)
Pages: 154-155
Section: Letters to the Editor
URL: https://journals.rcsi.science/1070-3632/article/view/218084
DOI: https://doi.org/10.1134/S107036321701025X
ID: 218084

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Abstract
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Abstract

The reaction in a mixture of 1,3-cyclohexanedione (dimedone), arylaldehyde, and ammonium acetate at 160°C during 10–15 min in the absence of solvent leads to the formation of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones. The structure of the products has been confirmed by IR and ¹H NMR spectroscopy data. Antimicrobial activity of the obtained compounds has been studied.

Keywords

9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2Н,5Н)-dione, Hantzsch synthesis, antimicrobial activity

About the authors

O. E. Nasakin

Chuvash State University

Email: geinvl48@mail.ru
Russian Federation, Cheboksary

M. I. Kazantseva