Email this article Synthesis and biological activity of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines
- Authors: Subhashini N.J.1, Reddy C.B.1, Kumar P.A.1, Lingaiah B.1
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Affiliations:
- Department of Chemistry, University College of Technology
- Issue: Vol 86, No 12 (2016)
- Pages: 2845-2848
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217025
- DOI: https://doi.org/10.1134/S1070363216120483
- ID: 217025
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Abstract
An efficient one-pot synthesis of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines is presented. This involves the three-component reaction of aldehydes with ketones and ammonium acetate in the presence of catalytic amount of iodine/AcOH. The newly synthesized compounds were characterized by IR, 1H, 13C NMR spectra, and MS data. The products were screened for antibacterial and antifungal activity. Some of the tested compounds exhibited high activity.
About the authors
N. J. P. Subhashini
Department of Chemistry, University College of Technology
Author for correspondence.
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
Ch. B. Reddy
Department of Chemistry, University College of Technology
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
P. A. Kumar
Department of Chemistry, University College of Technology
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
B. Lingaiah
Department of Chemistry, University College of Technology
Email: njsubhashini@yahoo.co.in
India, Hyderabad, 500007
