Synthesis and biological activity of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines


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Resumo

An efficient one-pot synthesis of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines is presented. This involves the three-component reaction of aldehydes with ketones and ammonium acetate in the presence of catalytic amount of iodine/AcOH. The newly synthesized compounds were characterized by IR, 1H, 13C NMR spectra, and MS data. The products were screened for antibacterial and antifungal activity. Some of the tested compounds exhibited high activity.

Sobre autores

N. Subhashini

Department of Chemistry, University College of Technology

Autor responsável pela correspondência
Email: njsubhashini@yahoo.co.in
Índia, Hyderabad, 500007

Ch. Reddy

Department of Chemistry, University College of Technology

Email: njsubhashini@yahoo.co.in
Índia, Hyderabad, 500007

P. Kumar

Department of Chemistry, University College of Technology

Email: njsubhashini@yahoo.co.in
Índia, Hyderabad, 500007

B. Lingaiah

Department of Chemistry, University College of Technology

Email: njsubhashini@yahoo.co.in
Índia, Hyderabad, 500007


Declaração de direitos autorais © Pleiades Publishing, Ltd., 2016

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