Synthesis and characterization of novel 5-allyl-6-{(benzo[d]thiazol-2-yl)methyl}-2-(alkylsulfanyl)oxopyrimidine derivatives


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Abstract

A series of novel S-DABO analogues bearing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b][1,3]thiazine has been developed starting from 5-allyl-6-{(benzo[d]thiazol-2-yl)methyl}-2,3-dihydro-2-thioxopyrimidin-4(1H)-one. Selective S-alkylation was achieved to give the title compounds which were cyclized and oxidized to the corresponding sulfones.

About the authors

N. M. Khalifa

Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division

Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622

M. A. Al-Omar

Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy

Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451

A. E. Amr

Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Applied Organic Chemistry Department

Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622


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