Synthesis and characterization of novel 5-allyl-6-{(benzo[d]thiazol-2-yl)methyl}-2-(alkylsulfanyl)oxopyrimidine derivatives

详细

A series of novel S-DABO analogues bearing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b][1,3]thiazine has been developed starting from 5-allyl-6-{(benzo[d]thiazol-2-yl)methyl}-2,3-dihydro-2-thioxopyrimidin-4(1H)-one. Selective S-alkylation was achieved to give the title compounds which were cyclized and oxidized to the corresponding sulfones.