Associates of thioalkyl derivatives of 2-arylaminopyrimidine with hydroxyapatite-based nanocomposites

Abstract

Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the composites of hydroxyapatite (HA) covered with nanoparticles of magnetite as well as compositions of magnetite, gold and silver. The thioalkyl-substituted derivatives of 2-arylaminopyrimidine, structural analogs of antitumor drug Imatinib containing one or two SH groups and capable to chemisorption on hydroxyapatite and its nanocomposites, have been synthesized. Two-component Fe₃O₄(HA) and three-component Fe₃O₄(HA)Au and Fe₃O₄(HA)Ag composites have been found the most promising as nanocarriers of bioactive compounds.