Catalytic alkylation of cycloalkaneindoles and tetrahydro-γ-carboline with 9-oxiranylmethylcarbazole


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Abstract

Catalytic alkylation of substituted indoles such as cycloalkaneindoles and tetrahydro-γ-carboline using 9-oxiranylmethylcarbazole leads to the formation of 1-(carbazol-9-yl)-3-{dihydrocycloalkane[b]indol-4(1H)-yl}propan-2-ols and 1-(carbazol-9-yl)-3-{2,8-dimethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl}propan-2-ol, conjugates containing 2-hydroxypropylene spacer.

About the authors

V. B. Sokolov

Institute of Physiologically Active Compounds

Email: alaks@ipac.ac.ru
Russian Federation, Severniy pr. 1, Chernogolovka, 142432

A. Yu. Aksinenko

Institute of Physiologically Active Compounds

Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, Severniy pr. 1, Chernogolovka, 142432

T. A. Epishina

Institute of Physiologically Active Compounds

Email: alaks@ipac.ac.ru
Russian Federation, Severniy pr. 1, Chernogolovka, 142432

T. V. Goreva

Institute of Physiologically Active Compounds

Email: alaks@ipac.ac.ru
Russian Federation, Severniy pr. 1, Chernogolovka, 142432


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