Email this article Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes
- Authors: Sinenko V.O.1, Slivchuk S.R.1, Pil’o S.G.1, Raenko G.F.2, Brovarets V.S.1
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Affiliations:
- Institute of Bioorganic Chemistry and Petrochemistry
- Litvinenko Institute of Physical Organic and Coal Chemistry
- Issue: Vol 86, No 7 (2016)
- Pages: 1597-1603
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215650
- DOI: https://doi.org/10.1134/S1070363216070100
- ID: 215650
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Abstract
Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were obtained. They are of interest as potential bioactive substances.
About the authors
V. O. Sinenko
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
S. R. Slivchuk
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
S. G. Pil’o
Institute of Bioorganic Chemistry and Petrochemistry
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
G. F. Raenko
Litvinenko Institute of Physical Organic and Coal Chemistry
Email: brovarets@bpci.kiev.ua
Ukraine, Kyiv
V. S. Brovarets
Institute of Bioorganic Chemistry and Petrochemistry
Author for correspondence.
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660
