Features of reactions of (E)-1-(β-aroylvinyl)pyridinium bromides with binucleophiles
- Authors: Khachikyan R.D.1, Ovakimyan Z.G.1, Panosyan G.A.1, Tamazyan R.A.1, Ayvazyan A.G.1
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Affiliations:
- Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 86, No 7 (2016)
- Pages: 1574-1580
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215639
- DOI: https://doi.org/10.1134/S1070363216070070
- ID: 215639
Cite item
Abstract
Regardless of pH and a solvent nature the reactions of (E)-1-(β-aroylvinyl)pyridinium bromides with hydrazine led to the formation of pyrazole derivatives. The salts reacted with thiourea via intermediate formation of 4-arylpyrimidine-2-thiol to give (Z)-2-[(β-aroylvinyl)sulfanyl]-4-arylpyrimidines. In the case of N,N'-diphenylthiourea the reaction provided 6-aryl-3-aroyl-1-phenylpyridinium bromides. Pyridine hydrobromide liberated in the reaction course has a major influence on the process chemoselectivity.
About the authors
R. Dzh. Khachikyan
Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: khachikyanraya@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
Z. G. Ovakimyan
Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: khachikyanraya@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
G. A. Panosyan
Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: khachikyanraya@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
R. A. Tamazyan
Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: khachikyanraya@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
A. G. Ayvazyan
Institute of Organic Chemistry, Scientific-Technological Center of Organic and Pharmaceutical Chemistry
Email: khachikyanraya@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
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