Email this article Synthesis and biological activity of new hybrids compounds derived from benzofuroxanes and polyene antibiotics
- Authors: Chugunova E.A.1, Mukhamatdinova R.E.2, Sazykina M.A.3, Sazykin I.S.3, Khammami M.I.3, Akylbekov N.I.2, Burilov A.R.1, Kulik N.V.1, Zobov V.V.1
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre
- Kazan State Technological University
- Ivanovskii Academy of Biology and Biotechnology
- Issue: Vol 86, No 5 (2016)
- Pages: 1037-1040
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214924
- DOI: https://doi.org/10.1134/S1070363216050091
- ID: 214924
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Abstract
Hybrid compounds based on 4,6-dichloro-5-nitrobenzofuroxan, 7-chloro-4,6-dinitrobenzofuroxan, 5,7-dichloro-4,6-dinitrobenzofuroxan, and polyene antibiotics (amphotericin B and nystatin) have been prepared for the first time. They have exhibited biological activity comparable to that of starting antibiotics. Activity of the compound derived from 5,7-dichloro-4,6-dinitrobenzofuroxan and nystatin towards Trichophyton mentagrophytes is 4 times higher than that of nystatin.
About the authors
E. A. Chugunova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre
Author for correspondence.
Email: elena-chugunova@list.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
R. E. Mukhamatdinova
Kazan State Technological University
Email: elena-chugunova@list.ru
Russian Federation, Kazan, Tatarstan
M. A. Sazykina
Ivanovskii Academy of Biology and Biotechnology
Email: elena-chugunova@list.ru
Russian Federation, Rostov-on-Don
I. S. Sazykin
Ivanovskii Academy of Biology and Biotechnology
Email: elena-chugunova@list.ru
Russian Federation, Rostov-on-Don
M. I. Khammami
Ivanovskii Academy of Biology and Biotechnology
Email: elena-chugunova@list.ru
Russian Federation, Rostov-on-Don
N. I. Akylbekov
Kazan State Technological University
Email: elena-chugunova@list.ru
Russian Federation, Kazan, Tatarstan
A. R. Burilov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre
Email: elena-chugunova@list.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
N. V. Kulik
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre
Email: elena-chugunova@list.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
V. V. Zobov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Centre
Email: elena-chugunova@list.ru
Russian Federation, ul. Akademika Arbuzova 8, Kazan, Tatarstan, 420088
