Email this article Charge-transfer complexes of two highly efficient drugs with σ- and π-acceptors: Spectroscopic, thermal, and surface morphology characteristics
- Authors: Naglah A.M.1,2, Al-Omar M.A.1, Ibrahim O.B.3, Refat M.S.3,4, Adam A.M.3, Saad H.A.3,5, El-Metwaly N.M.6,7
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Affiliations:
- Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy
- Peptide Chemistry Department, Chemical Industries Research Division
- Department of Chemistry, Faculty of Sciences
- Department of Chemistry, Faculty of Science, Port Said
- Department of Chemistry, Faculty of Science
- Chemistry Department, College of Applied Sciences
- Chemistry Department, Faculty of Science
- Issue: Vol 86, No 4 (2016)
- Pages: 965-974
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214846
- DOI: https://doi.org/10.1134/S1070363216040356
- ID: 214846
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Abstract
Considerable attention has recently been devoted to the formation of stable charge-transfer (CT) complexes that result from the reaction of drugs with acceptors. Intermolecular CT interactions of two drugs, barbituratic acid (Bar) and ephedrine hydrochloride (Eph), with different σ- and π-acceptors have been studied stoichiometrically, structurally (IR, Raman, 1H NMR, and UV-Vis spectroscopy), thermally, and morphologically (SEM).
About the authors
A. M. Naglah
Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy; Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
M. A. Al-Omar
Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451
O. B. Ibrahim
Department of Chemistry, Faculty of Sciences
Email: msrefat@yahoo.com
Saudi Arabia, Taif, 21974
M. S. Refat
Department of Chemistry, Faculty of Sciences; Department of Chemistry, Faculty of Science, Port Said
Author for correspondence.
Email: msrefat@yahoo.com
Saudi Arabia, Taif, 21974; Port
A. M. A. Adam
Department of Chemistry, Faculty of Sciences
Email: msrefat@yahoo.com
Saudi Arabia, Taif, 21974
H. A. Saad
Department of Chemistry, Faculty of Sciences; Department of Chemistry, Faculty of Science
Email: msrefat@yahoo.com
Saudi Arabia, Taif, 21974; Zagazig
N. M. El-Metwaly
Chemistry Department, College of Applied Sciences; Chemistry Department, Faculty of Science
Email: msrefat@yahoo.com
Saudi Arabia, Makkah; Mansoura
