Synthesis, spectral, antimicrobial, and thermal properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) gliclazide complexes
- Authors: Abd El-Wahed M.G.1, El-Megharbel S.M.1,2, El-Sayed M.Y.1, Zahran Y.M.1, Refat M.S.2,1, Al-Omar M.A.3, Naglah A.M.3,4
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Affiliations:
- Department of Chemistry, Faculty of Science
- Department of Chemistry, Faculty of Sciences
- Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy
- Peptide Chemistry Department, Chemical Industries Research Division
- Issue: Vol 86, No 2 (2016)
- Pages: 391-399
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/213985
- DOI: https://doi.org/10.1134/S1070363216020328
- ID: 213985
Cite item
Abstract
The complexation between the lanthanide metal ions Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) and gliclazide produced 1 : 1 molar ratio metal: gliclazide (Glz) complexes coordinated in a monodentate fashion via the OH group and having the general formulas [M(Glz)Cl3(H2O)]·xH2O (M = Ce, Gd, Nd and x = 1, 3, 4, respectively) and [M(Glz)(H2O)4]Cl3·yH2O (M = Tb, Er and y = 1, 2, respectively). The structure of the synthesized lanthanide gliclazide complexes was assigned by IR, 1HNMR, and UV-Vis spectroscopy. Thermal analysis and kinetic and thermodynamic parameters gave evidence for the thermal stability of the Glz complexes. The latter showed a significant antimicrobial effect against some bacteria and fungi.
Keywords
About the authors
M. G. Abd El-Wahed
Department of Chemistry, Faculty of Science
Email: msrefat@yahoo.com
Egypt, Zagazig
S. M. El-Megharbel
Department of Chemistry, Faculty of Science; Department of Chemistry, Faculty of Sciences
Email: msrefat@yahoo.com
Egypt, Zagazig; Al-Haweiah, Taif, 21974
M. Y. El-Sayed
Department of Chemistry, Faculty of Science
Email: msrefat@yahoo.com
Egypt, Zagazig
Y. M. Zahran
Department of Chemistry, Faculty of Science
Email: msrefat@yahoo.com
Egypt, Zagazig
M. S. Refat
Department of Chemistry, Faculty of Sciences; Department of Chemistry, Faculty of Science
Author for correspondence.
Email: msrefat@yahoo.com
Saudi Arabia, Al-Haweiah, Taif, 21974; Port Said
M. A. Al-Omar
Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451
A. M. Naglah
Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy; Peptide Chemistry Department, Chemical Industries Research Division
Email: msrefat@yahoo.com
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
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