Synthesis and Antimicrobial and Antifungal Activity of Resin Acid Acetylene Derivatives
- 作者: Tretyakova E.1, Salimova E.1, Parfenova L.1
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隶属关系:
- Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
- 期: 卷 45, 编号 6 (2019)
- 页面: 545-551
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229251
- DOI: https://doi.org/10.1134/S1068162019050121
- ID: 229251
如何引用文章
详细
A series of diterpenes that contain the morpholine, pyrrolidine, benzyl, nitrophenyl, and 1,2,3-tetrazole heterocyclic fragments have been synthesized from acetylene derivatives of abietic, 7-formylabietic, dehydroabietic, maleopimaric, and dihydroquinopimaric acids. The antibacterial activity of the synthesized compounds against microorganisms and pathogenic fungi has been studied, and the primary assessment of their cytotoxicity and hemolytic activity has have been carried out. It has been found that the acetylene derivatives of abietic and dehydroabietic acids that contain the pyrrolidine substituent can effectively inhibit the growth of fungi Candida albicans and Cryptococcus neoformans, and their low hemolytic ability has been shown.
作者简介
E. Tretyakova
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: tretyakovaelv@gmail.com
俄罗斯联邦, Ufa, 450075
E. Salimova
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
Email: tretyakovaelv@gmail.com
俄罗斯联邦, Ufa, 450075
L. Parfenova
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
Email: tretyakovaelv@gmail.com
俄罗斯联邦, Ufa, 450075