Synthesis and Antimicrobial and Antifungal Activity of Resin Acid Acetylene Derivatives
- Авторы: Tretyakova E.1, Salimova E.1, Parfenova L.1
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Учреждения:
- Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
- Выпуск: Том 45, № 6 (2019)
- Страницы: 545-551
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229251
- DOI: https://doi.org/10.1134/S1068162019050121
- ID: 229251
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Аннотация
A series of diterpenes that contain the morpholine, pyrrolidine, benzyl, nitrophenyl, and 1,2,3-tetrazole heterocyclic fragments have been synthesized from acetylene derivatives of abietic, 7-formylabietic, dehydroabietic, maleopimaric, and dihydroquinopimaric acids. The antibacterial activity of the synthesized compounds against microorganisms and pathogenic fungi has been studied, and the primary assessment of their cytotoxicity and hemolytic activity has have been carried out. It has been found that the acetylene derivatives of abietic and dehydroabietic acids that contain the pyrrolidine substituent can effectively inhibit the growth of fungi Candida albicans and Cryptococcus neoformans, and their low hemolytic ability has been shown.
Об авторах
E. Tretyakova
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: tretyakovaelv@gmail.com
Россия, Ufa, 450075
E. Salimova
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
Email: tretyakovaelv@gmail.com
Россия, Ufa, 450075
L. Parfenova
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences
Email: tretyakovaelv@gmail.com
Россия, Ufa, 450075