Optimization of Fungal Luciferin Synthesis
- 作者: Bubyrev A.1, Tsarkova A.1,2, Kaskova Z.1,2
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隶属关系:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Pirogov Russian National Research Medical University
- 期: 卷 45, 编号 2 (2019)
- 页面: 183-185
- 栏目: Letter to Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/229189
- DOI: https://doi.org/10.1134/S106816201902002X
- ID: 229189
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详细
Current studies of fungal bioluminescent systems, including the purification of luciferase, require large quantities of the synthetic substrate luciferin available. The existing synthetic method for the luciferin produces low yield of the target molecule. In the current work, the synthesis of fungal luciferin was scaled up to gram quantities and an effective method for its final purification was found. The total yield in comparison with the previous method was increased by 3.5 times; the overall cost of synthesis fell by 3 times.
作者简介
A. Bubyrev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: zkaskova@ibch.ru
俄罗斯联邦, Moscow, 117997
A. Tsarkova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pirogov Russian National Research Medical University
Email: zkaskova@ibch.ru
俄罗斯联邦, Moscow, 117997; Moscow, 117997
Z. Kaskova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: zkaskova@ibch.ru
俄罗斯联邦, Moscow, 117997; Moscow, 117997