Отправить статью по E-mail Optimization of Fungal Luciferin Synthesis
- Авторы: Bubyrev A.I.1, Tsarkova A.S.1,2, Kaskova Z.M.1,2
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Учреждения:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Pirogov Russian National Research Medical University
- Выпуск: Том 45, № 2 (2019)
- Страницы: 183-185
- Раздел: Letter to Editor
- URL: https://journals.rcsi.science/1068-1620/article/view/229189
- DOI: https://doi.org/10.1134/S106816201902002X
- ID: 229189
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Аннотация
Current studies of fungal bioluminescent systems, including the purification of luciferase, require large quantities of the synthetic substrate luciferin available. The existing synthetic method for the luciferin produces low yield of the target molecule. In the current work, the synthesis of fungal luciferin was scaled up to gram quantities and an effective method for its final purification was found. The total yield in comparison with the previous method was increased by 3.5 times; the overall cost of synthesis fell by 3 times.
Об авторах
A. Bubyrev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: zkaskova@ibch.ru
Россия, Moscow, 117997
A. Tsarkova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pirogov Russian National Research Medical University
Email: zkaskova@ibch.ru
Россия, Moscow, 117997; Moscow, 117997
Z. Kaskova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pirogov Russian National Research Medical University
Автор, ответственный за переписку.
Email: zkaskova@ibch.ru
Россия, Moscow, 117997; Moscow, 117997
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