Synthesis and Biological Activity of 3,4,-Tri-О-Acetyl-N-Acetylglucosamine and Tetraacetylglucopyranose Conjugated with Alkyl Phosphates
- 作者: Sharipova R.1, Garifullin B.1, Sapunova A.1, Voloshina A.1, Kravchenko M.2, Kataev V.1
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隶属关系:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
- Ural Research Institute for Phthisiopulmonology
- 期: 卷 45, 编号 2 (2019)
- 页面: 155-164
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229179
- DOI: https://doi.org/10.1134/S1068162019020110
- ID: 229179
如何引用文章
详细
Conjugates of 3,4,6-tri-О-acetyl-N-acetylglucosamine and tetraacetyl glucopyranose with alkyl phosphates were synthesized. The dependence of their antibacterial and antituberculosis activities on the length of the alkyl substituent at the phosphate group was found. The conjugates with a decyl substituent exhibited in vitro the highest antituberculosis activity against Mycobacterium tuberculosis H37Rv (MIC 3 µg/mL) but the weakest effect towards Streptococcus aureus and Bacillus cereus (≤MIC 125 µg/mL). Vice versa, the conjugates with a cetyl substituent demonstrated the highest antibacterial activity in vitro towards S. aureus and B. cereus (MIC 16 µg/mL) but showed the lowest antituberculosis activity (MIC 12 µg/mL) among the compounds under study.
作者简介
R. Sharipova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
俄罗斯联邦, Kazan, 420088
B. Garifullin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
俄罗斯联邦, Kazan, 420088
A. Sapunova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
俄罗斯联邦, Kazan, 420088
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
俄罗斯联邦, Kazan, 420088
M. Kravchenko
Ural Research Institute for Phthisiopulmonology
Email: kataev@iopc.ru
俄罗斯联邦, Yekaterinburg, 620039
V. Kataev
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: kataev@iopc.ru
俄罗斯联邦, Kazan, 420088