Synthesis and Biological Activity of 3,4,-Tri-О-Acetyl-N-Acetylglucosamine and Tetraacetylglucopyranose Conjugated with Alkyl Phosphates
- Авторы: Sharipova R.1, Garifullin B.1, Sapunova A.1, Voloshina A.1, Kravchenko M.2, Kataev V.1
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Учреждения:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
- Ural Research Institute for Phthisiopulmonology
- Выпуск: Том 45, № 2 (2019)
- Страницы: 155-164
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229179
- DOI: https://doi.org/10.1134/S1068162019020110
- ID: 229179
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Аннотация
Conjugates of 3,4,6-tri-О-acetyl-N-acetylglucosamine and tetraacetyl glucopyranose with alkyl phosphates were synthesized. The dependence of their antibacterial and antituberculosis activities on the length of the alkyl substituent at the phosphate group was found. The conjugates with a decyl substituent exhibited in vitro the highest antituberculosis activity against Mycobacterium tuberculosis H37Rv (MIC 3 µg/mL) but the weakest effect towards Streptococcus aureus and Bacillus cereus (≤MIC 125 µg/mL). Vice versa, the conjugates with a cetyl substituent demonstrated the highest antibacterial activity in vitro towards S. aureus and B. cereus (MIC 16 µg/mL) but showed the lowest antituberculosis activity (MIC 12 µg/mL) among the compounds under study.
Об авторах
R. Sharipova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
Россия, Kazan, 420088
B. Garifullin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
Россия, Kazan, 420088
A. Sapunova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
Россия, Kazan, 420088
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Email: kataev@iopc.ru
Россия, Kazan, 420088
M. Kravchenko
Ural Research Institute for Phthisiopulmonology
Email: kataev@iopc.ru
Россия, Yekaterinburg, 620039
V. Kataev
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: kataev@iopc.ru
Россия, Kazan, 420088