Amino Derivatives of Natural Epoxyalantolactone: Synthesis and Cytotoxicity toward Tumor Cells
- 作者: Pukhov S.1, Afanasyeva S.1, Anikina L.1, Semakov A.1, Dubrovskaya E.1, Klochkov S.1
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隶属关系:
- Institute of Physiologically Active Compounds
- 期: 卷 44, 编号 5 (2018)
- 页面: 553-561
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229028
- DOI: https://doi.org/10.1134/S1068162018040155
- ID: 229028
如何引用文章
详细
Reactions of natural epoxyalantolactone with primary and secondary amines, which lead to hydrated benzo[g]furo[4,3,2-cd]indolones and eudesmane-type amino derivatives, respectively, have been studied. Epoxyalantolactone conjugates have been synthesized with the involvement of pharmacophoric amines, and their cytotoxic activity toward some tumor cell lines has been tested. The involvement of the signaling pathway of protein p53 in the death of tumor cells, the contribution of oxidative stress, and the induction of apoptosis have been investigated in experiments in vitro.
作者简介
S. Pukhov
Institute of Physiologically Active Compounds
编辑信件的主要联系方式.
Email: pukhov.sergey@gmail.com
俄罗斯联邦, Chernogolovka, Moscow oblast, 142432
S. Afanasyeva
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
俄罗斯联邦, Chernogolovka, Moscow oblast, 142432
L. Anikina
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
俄罗斯联邦, Chernogolovka, Moscow oblast, 142432
A. Semakov
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
俄罗斯联邦, Chernogolovka, Moscow oblast, 142432
E. Dubrovskaya
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
俄罗斯联邦, Chernogolovka, Moscow oblast, 142432
S. Klochkov
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
俄罗斯联邦, Chernogolovka, Moscow oblast, 142432