Amino Derivatives of Natural Epoxyalantolactone: Synthesis and Cytotoxicity toward Tumor Cells
- Authors: Pukhov S.A.1, Afanasyeva S.V.1, Anikina L.V.1, Semakov A.V.1, Dubrovskaya E.S.1, Klochkov S.G.1
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Affiliations:
- Institute of Physiologically Active Compounds
- Issue: Vol 44, No 5 (2018)
- Pages: 553-561
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229028
- DOI: https://doi.org/10.1134/S1068162018040155
- ID: 229028
Cite item
Abstract
Reactions of natural epoxyalantolactone with primary and secondary amines, which lead to hydrated benzo[g]furo[4,3,2-cd]indolones and eudesmane-type amino derivatives, respectively, have been studied. Epoxyalantolactone conjugates have been synthesized with the involvement of pharmacophoric amines, and their cytotoxic activity toward some tumor cell lines has been tested. The involvement of the signaling pathway of protein p53 in the death of tumor cells, the contribution of oxidative stress, and the induction of apoptosis have been investigated in experiments in vitro.
About the authors
S. A. Pukhov
Institute of Physiologically Active Compounds
Author for correspondence.
Email: pukhov.sergey@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
S. V. Afanasyeva
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
L. V. Anikina
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
A. V. Semakov
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
E. S. Dubrovskaya
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
S. G. Klochkov
Institute of Physiologically Active Compounds
Email: pukhov.sergey@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432