Synthesis and Biological Activity of Nitrilic Derivatives of the Methyl Ester of Maleopimaric Acid

E. V. Tret’yakova; E. V. Salimova; L. V. Parfenova

doi:10.1134/S1068162018050175

Synthesis and Biological Activity of Nitrilic Derivatives of the Methyl Ester of Maleopimaric Acid

作者: Tret’yakova E.V.¹, Salimova E.V.¹, Parfenova L.V.¹
隶属关系:
1. Institute of Petrochemistry and Catalysis
期: 卷 44, 编号 5 (2018)
页面: 547-552
栏目: Article
URL: https://journals.rcsi.science/1068-1620/article/view/229024
DOI: https://doi.org/10.1134/S1068162018050175
ID: 229024

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An effective method of a modification of the anhydride ring of the maleopimaric acid methyl ester by means of the cyanoethylation reaction was developed. A primary screening of a cytotoxic activity in vitro demonstrated an ability of the cyanoethyl derivative of the maleopimaric acid methyl ester to induce the death of the PC-3 cells of prostate cancer.