Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments
- 作者: Voloshina A.1, Semenov V.1, Strobykina A.1, Kulik N.1, Krylova E.1, Zobov V.1, Reznik V.1
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隶属关系:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
- 期: 卷 43, 编号 2 (2017)
- 页面: 170-176
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228468
- DOI: https://doi.org/10.1134/S1068162017020170
- ID: 228468
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详细
The antimicrobial activity and cytotoxicity of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments in alkyl chains have been studied. The compounds have been tested for the antimicrobial activity toward some gram-positive and gram-negative bacteria and fungal cultures. The cytotoxic action has been estimated toward mammalian cells. It has been found that the basic structural factor that affects the antimicrobial activity is the nature of alkyl radicals at triazole fragments.
作者简介
A. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
编辑信件的主要联系方式.
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088
V. Semenov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088
A. Strobykina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088
N. Kulik
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088
E. Krylova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088
V. Zobov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088
V. Reznik
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
俄罗斯联邦, Kazan, 420088