Synthesis and antimicrobial and toxic properties of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments
- Authors: Voloshina A.D.1, Semenov V.E.1, Strobykina A.S.1, Kulik N.V.1, Krylova E.S.1, Zobov V.V.1, Reznik V.S.1
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
- Issue: Vol 43, No 2 (2017)
- Pages: 170-176
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228468
- DOI: https://doi.org/10.1134/S1068162017020170
- ID: 228468
Cite item
Abstract
The antimicrobial activity and cytotoxicity of novel 1,3-bis(alkyl)-6-methyluracil derivatives containing 1,2,3- and 1,2,4-triazolium fragments in alkyl chains have been studied. The compounds have been tested for the antimicrobial activity toward some gram-positive and gram-negative bacteria and fungal cultures. The cytotoxic action has been estimated toward mammalian cells. It has been found that the basic structural factor that affects the antimicrobial activity is the nature of alkyl radicals at triazole fragments.
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About the authors
A. D. Voloshina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Author for correspondence.
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088
V. E. Semenov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088
A. S. Strobykina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088
N. V. Kulik
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088
E. S. Krylova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088
V. V. Zobov
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088
V. S. Reznik
Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center
Email: microbi@iopc.ru
Russian Federation, Kazan, 420088