Molecular mechanisms of antitumor effect of natural antimicrobial peptides
- 作者: Balandin S.1, Emelianova A.1, Kalashnikova M.1, Kokryakov V.2,3, Shamova O.2,3, Ovchinnikova T.1
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隶属关系:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Institute of Experimental Medicine
- St. Petersburg State University
- 期: 卷 42, 编号 6 (2016)
- 页面: 575-589
- 栏目: Review Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228175
- DOI: https://doi.org/10.1134/S1068162016060029
- ID: 228175
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详细
In spite of all the advances in cancer treatment made in recent years, one of the main problems in this field that remains extremely urgent is the development of drug resistance to the chemotherapeutic agents currently in use due to clonal microevolution of tumor tissue. Numerous publications devoted to the study of cationic antimicrobial peptides (AMPs) as molecular factors of the innate immune system suggest that these compounds possess significant therapeutic potential and can be considered as candidates for the role of not only antimicrobial, but also next-generation anticancer drugs. AMPs are characterized by a variety of mechanisms of cytotoxic action that can lead to either necrosis or apoptosis of the target cells. These effects are based on the selective interaction with the membranes of tumor cells, which have a number of similarities, in structural and physiological aspects, with the microbial membranes. AMPs were found to be able to inhibit tumor growth by interrupting the formation of its vascular network. The antitumor effect of AMPs may also be enhanced by the modulation of host immune system, as previously observed for their antimicrobial effects. The described properties of AMPs give hope for the development of new drugs that will be able to overcome the resistance of tumor cells.
作者简介
S. Balandin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ovch@ibch.ru
俄罗斯联邦, Moscow, 117997
A. Emelianova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ovch@ibch.ru
俄罗斯联邦, Moscow, 117997
M. Kalashnikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: ovch@ibch.ru
俄罗斯联邦, Moscow, 117997
V. Kokryakov
Institute of Experimental Medicine; St. Petersburg State University
Email: ovch@ibch.ru
俄罗斯联邦, St. Petersburg, 197376; St. Petersburg, 199034
O. Shamova
Institute of Experimental Medicine; St. Petersburg State University
Email: ovch@ibch.ru
俄罗斯联邦, St. Petersburg, 197376; St. Petersburg, 199034
T. Ovchinnikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: ovch@ibch.ru
俄罗斯联邦, Moscow, 117997